This article examines the nature of religious interactions in the Muslim stronghold town of Ede in southwest Nigeria between the Muslim majority and the Christian minority. In particular, it examines the conflict that arose between Muslim and Christian groups in the town over the famous Christian programme, “Healing Jesus Crusade” in 2011. The programme represents the height of religious misunderstanding in Ede as the situation almost degenerated into open conflict between Muslims and Christians during this period. This article looks at the fundamental and immediate causes of the conflict, as well as the nature of the conflict, its implications for religious interactions in Ede, and the methods adopted in resolving the conflict. Based on oral interviews and the use of extant literature, this article contends that the crisis surrounding the “Healing Jesus Crusade” was a manifestation of the “aggressive” Christian evangelism in the Muslim-dominated town of Ede, and the “radical” reactions of the Muslim majority to maintain the status quo of the dominance of Islam in the town.